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Arterial Stiffness

Renal Denervation Improves Blood Pressure And Arterial Stiffness
Published: August 27, 2012.
By European Society of Cardiology

Munich, Germany – August 27 2012: Renal denervation improves blood pressure and arterial stiffness in patients with therapy resistant hypertension, according to research presented at ESC Congress 2012 by Mr Klaas Franzen from the University Hospital of Schleswig-Holstein. The findings suggest that renal denervation regenerates blood vessels and could reduce cardiovascular events.
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Malignant arterial hypertension was historically treated with surgical thoracolumbar splanchnicectomy, a type of sympathectomy treatment that was introduced in 1938. "A significant reduction in blood pressure response was observed in at least half of the patients who underwent splanchnicectomy," said Mr Franzen. "But the treatment led to severe adverse events such as orthostatic hypotension, anhidrosis and intestinal disturbances. After the discovery of effective antihypertensive drugs, splanchnicectomy became neglected and disregarded over time."
In 2009 the concept of sympathectomy was reintroduced with intravasal catheter-based percutaneous renal sympathetic denervation (RDN) used in patients suffering from resistant arterial hypertension. Recent publications have shown that RDN significantly lowers systolic and diastolic peripheral brachial blood pressure by 32/12 mmHg after 6 months.
Mr Franzen said: "RDN with radiofrequency energy has several important advantages over surgical splanchnicectomy: it is a minimally invasive procedure without significant systematic side effects, it is well tolerated, and recovery times are short."
Arterial hypertension can irrevocably harm blood vessels in the short and long term, subsequently leading to increased aortic/arterial stiffness and arteriosclerosis. "Since central aortic pressures and arterial stiffness are much better predictors for future cardiovascular events than peripheral pressures we focused the present study on the effects of RDN on central hemodynamics and arterial stiffness," said Mr Franzen.
The researchers studied 21 patients with therapy resistant hypertension (61.9% men; mean age 64 years; 5.0±1.3 antihypertensive drugs) and 6 controls (83.3% men; mean age 57 years; 4.3±2.3 antihypertensive drugs). The inclusion criteria were: (i) use of >3 antihypertensive drugs, (ii) peripheral blood pressure at baseline ≥150 mmHg, and (iii) exclusion of secondary hypertension and anatomical abnormalities of the renal arteries.
RDN was performed with an RDN radiofrequency ablation catheter system (1). Central hemodynamics and arterial stiffness, i.e. pulse wave velocity (PWV), were recorded with an Arteriograph device (2). Measurements were performed at baseline, and 3 and 6 months after the intervention.
RDN led to an improvement in all parameters compared to baseline. Peripheral systolic blood pressure improved by 7.6% (145 mmHg versus 156 mmHg, p<0.05) after 3 months and by 5.4% (148 mmHg versus 156 mmHg, p<0.05) after 6 months. Central systolic blood pressure improved by 9.5% (147 mmHg versus 161 mmHg, p<0.01) after 3 months and by 6.6% (151 mmHg versus 161 mmHg, p<0.05) after 6 months. Most importantly, PWV improved significantly, both at 3 months (9.4±1.2 m/s versus 10.9±1.8 m/s, p<0.01) and 6 months (9.7±1.8 m/s versus 10.9±1.8 m/s, p<0.01). Univariate analysis of variance (f-test) showed that the improvement of PWV was, at least in part, blood pressure independent.
In controls no significant changes in blood pressure values or PWV were observed.
"Besides peripheral blood pressures, RDN improved central blood pressures and arterial stiffness, i.e. PWV," said Mr Franzen. "According to age adjusted reference values, the improvement of approximately 1m/s PWV observed in our study could be interpreted as a blood vessel rejuvenation of almost 10 years. This suggests that RDN might be a fountain of youth for blood vessels in patients with therapy resistant hypertension."
He added: "Further studies are needed to determine whether the benefits of RDN translate into a reduced risk of cardiovascular events."
by suwataisya | 2014-05-28 17:13 | 動脈硬化



by suwataisya | 2014-05-28 17:00 | 動脈硬化

新発売 ワイヤレス 携帯 動脈硬化指標計測計



by suwataisya | 2014-04-24 09:29 | 動脈硬化



Wireless Mobile 12 leads ECG Cloud Cardiology Systemとして、あるいは
12 leads ECG Transmission Fujinokuni として、すでに文献が発表されている
Hungary 国 Labtech 社のワイヤレス12誘導心電計シリーズ(血圧付き負荷心電計
by suwataisya | 2014-01-05 15:14 | 動脈硬化

original, patented oscillometric method

The Arteriograph
Arteriograph is a new diagnostic method that can offer reliable and easily understandible information for the patient about endothelial function, central blood pressure and large artery characteristics, which independently and all together are significant determinants of cardiovascular risk.
Medical research over the past decade has provided new possibilities for identifying early stage arterial stiffening via testing of large artery compliance. A significant number of broad, international studies and conclusions, and international studies designated as “evidence-based medicine” support the effectiveness of arterial stiffness related to cardiovascular disease and its prediction. Previously these important characteristics could only be tested under clinical conditions. As a result of the change in approach in this area, devices that are easy and safe to use have appeared, which are able to measure the parameters that indicate arterial function.
The Arteriograph, developed in Hungary and patented in over 30 countries, can measure in a procedure performed on a patient, similarly to a blood pressure measurement, the biological characteristics of the condition of the arteries, which independent of the other well-known classic risk factors (age, sex, blood pressure, cholesterol level, smoking habits), reliably indicates the cardiovascular condition of an asymptomatic patient and his/her risk level, and also assists in adjusting existing blood pressure reduction therapy to an exact and individualized level.

This original, patented oscillometric method, which has also been proven invasively, obtains information from the analysis of the pulse pressure curve registered in the upper arm. The special, so-called stop-flow method, i.e. the complete occlusion of the brachial artery eliminates the distortion of the pressure curve, so that the pressure curves are clearly recognizable and suitable for analysis. The occlusive measurement period lasts just a few seconds. The analytic software does not employ a mathematically generalized transfer function. The determination of the position and the amplitude of the reflective wave enable simultaneous and simple determination of pulse wave velocity, the augmentation index and the central blood pressure, as well as complementing the traditional blood pressure measurement data (systolic, diastolic blood pressure, arterial medial pressure, pulse) with further hemodynamic parameters.
by suwataisya | 2013-12-18 11:10 | 動脈硬化


ドイツ  医学 科学誌掲載         2005年
oszillometrisch mit Arteriograph (TensioMed, Budapest)

J. Baulmann - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
S. Rickert - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
U. Schillings - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
S. Uen - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
R. D・ing - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
H. Vetter - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
T. Mengden - Medizinische Polliklinik der Unviersit Bonn (Bonn, D)
Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. D・seldorf, Kn: German Medical Science; 2006. Doc05hochP109
Die elektronische Version dieses Artikels ist vollstdig und ist verf・bar unter:

Veröffentlicht:8. August 2006
© 2006 Baulmann et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielf舁tigt, verbreitet und fentlich zug舅glich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Einleitung: Der Augmentations-Index (AIx) quantifiziert die Pulswellen-Reflexion, ist ein direktes Ma゚ f・ Gefalter, ein indirektes Ma゚ f・ arterielle Gefsteifigkeit und eng verkn・ft mit kardiovaskulem Gesamt-Risiko. K・zlich wurde eine neue Methode entwickelt, welche aus oszillometrisch am Oberarm aufgezeichneten Blutdruckkurven den AIx analysiert. Ziel unserer Studie ist, die herkmliche, als Goldstandard angesehene, applanationstonometrische (SphygmoCor) mit der neuen oszillometrischen Methode, die Augmentation zu bestimmen, (Arteriograph) zu vergleichen.
Material und Methoden: Bei 41 Patienten und Probanden im Alter von 22-74 Jahren wurde jeweils 2 mal tonometrisch mit SphygmoCor (AtCor Medical, Sydney) sowie 4mal oszillometrisch mit Arteriograph (TensioMed, Budapest) der AIx bestimmt. Anschlie゚end wurden die Korrelationen zueinander sowie zum Alter berechnet.
Ergebnisse: Die Korrelation des AIx von Applanationstonometrie zu oszillometrischer Methode ist hoch signifikant mit r=0,809 (p<0,0001) und rイ=0,655. Zum Alter waren beiden Methoden nlich hoch signifikant mit r=0,76 (SphygmoCor) und r=0,72 (Arteriograph).
Schlussfolgerung: Die oszillometrische Bestimmung der Augmentation mittels des sehr einfach anzuwendenden, Untersucher-unabhgigen und kosteng・stigen Arteriograph birgt ein gro゚es klinisches Potential zur kardiovaskulen Risikostratifizierung.
by suwataisya | 2013-12-18 11:08 | 動脈硬化

Arteriograph 2013.6 ESH2013

by suwataisya | 2013-12-18 11:07 | 動脈硬化

Aerweial Stiffness

Hungary's "tensio arteriograph" - a simple way of examining our veins
27-01-2006 11:38 | Sándor Laczkó
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Cardio-vascular disease is the leading cause of death in Hungary and much of the rest of the world. Problems are often detected too late because many people do not suffer obvious symptoms. Even suspect cases can be difficult to confirm. But that may soon be history thanks to a new device invented by Hungarian doctor Miklos Illyes.
The "tensio arteriograph" is the first and so far only device that provides us with a fast and easy way of obtaining cardiac data that in the past could only be obtained through complicated and sometimes painful screenings.
"The medical profession was lacking a proper method to determine these data, called 'arterial stiffness parameters', namely, the augmentation index and the pulse rate velocity of the human aorta. So, this method before was determined by very specific procedures, very difficult methods, which needed a lot of time and a lot of expert knowledge of how to perform the examination."
Tensio arteriograph Says, doctor Miklos Illyes, the inventor of the tensio arteriograph. So how does it work? It's much simpler than one might expect. The arteriograph detects the condition of our veins in a procedure that's just as easy as taking our blood pressure.
"We discovered a new method how to assess the so-called arterial stiffness non-invasively with a very fast method, which needs only two minutes to determine the arterial age of the patient. This novelty consists of the fact that we use a simple cough to determine important central human dynamical parameters. This makes it possible for us to use this method for everyday practice and to screen the patient for arteriosclerosis. We do feel that in a few years, this kind of method will be used generally not only to check blood pressure but to have much more information about arterial stiffness beyond blood pressure measurement."
Dr. Laszlo Tisler of the St. Imre Hospital in Budapest was one of the first physicians to use it:
"My experience over all is very positive. It uses a very new way of assessing the compliance of large blood vessels. This information is substantial because it is associated with the survival of our patients - in particular, with patients of higher cardiovascular risk. The information this device provides is extremely helpful in those with high risk, and this may add new information, information on compliance of the vessel, or stiffness of the vessel, may provide information on those who have no other risk factors and this may be a very early sign of cardiovascular risk."
by suwataisya | 2013-12-10 01:02 | 動脈硬化

Arterial Stiffness

Arterial Assessment Validation Publications

Baulmann, J. et al.
“A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezoelectronic methods”
J Hypertension 2008, 26:523-528

Jatoi, N.A., et al.
“Assessment of arterial stiffness in hypertension: comparison of oscillometric (Arteriograph), piezoelectronic (Complior) and tonometric (SphygmoCor) techniques”
H Hypertension 2009, 27:2186-2191

Boutouyrie P, Revera M and Parati G.
“Obtaining arterial stiffness indices from simple arm cuff measurements: the holy grail?”
J Hypertension 2009; 27: 2159-2161

Rajzer MW, Wojciechowska W, Klocek M, Palka I, Brzozowska-Kiszka M, Kawecka-Jaszcz K.
“Comparison of aortic pulse wave velocity measured by three techniques: Coplior, SphygmoCor and Arteriograph.”
J Hypertension 2008; 26:2001-7

Horvath, G.I. et al.
“Invasive validation of a new oscillometric device (Arteriograph) for measuring augmentation index, central blood pressure and aortic pulse wave velocity.:
J Hypertension 2010, 28:2068-2075

Parati G, Buyzere de M
“Evaluating aortic stiffness through an arm cuff oscillometric device: is validation against invasive measurements enough?”
Journal of Hypertension 2010, 28:2003-2006
by suwataisya | 2013-12-10 01:00 | 動脈硬化


by suwataisya | 2013-12-10 00:41 | 動脈硬化

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